ODC1 (ornithine decarboxylase 1)

2003-08-01  

Identity

HGNC
ODC1
LOCATION
2p25.1
LOCUSID
4953
ALIAS
BABS,NEDBA,NEDBIA,ODC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4953
MIM: 165640
HGNC: 8109
Ensembl: ENSG00000115758

Variants:

dbSNP: 4953
ClinVar: 4953
TCGA: ENSG00000115758
COSMIC: ODC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115758ENST00000234111P11926
ENSG00000115758ENST00000405333P11926
ENSG00000115758ENST00000443218C9JG30

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Glutathione metabolismKEGGko00480
Arginine and proline metabolismKEGGhsa00330
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGhsa_M00134
Polyamine biosynthesis, arginine => ornithine => putrescineKEGGM00134
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446108Colorectal NeoplasmsDiseaseVariantAnnotationnot associatedPD
PA448497aspirinChemicalVariantAnnotationnot associatedPD

References

Pubmed IDYearTitleCitations
384737162024Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase.0
386480792024Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy.0
387438202024FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth.1
384737162024Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase.0
386480792024Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy.0
387438202024FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth.1
357351882022Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase.0
357351882022Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase.0
333054062021Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase.15
338060762021Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development.10
342827222021Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease.11
343768082021Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus.2
344772862021Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome.8
347968992021Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.3
333054062021Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase.15

Citation

Dessen P

ODC1 (ornithine decarboxylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41603