P2RY2 (purinergic receptor P2Y2)

2003-10-01  

Identity

HGNC
P2RY2
LOCATION
11q13.4
LOCUSID
5029
ALIAS
HP2U,P2RU1,P2U,P2U1,P2UR,P2Y2,P2Y2R

Other Information

Locus ID:

NCBI: 5029
MIM: 600041
HGNC: 8541
Ensembl: ENSG00000175591

Variants:

dbSNP: 5029
ClinVar: 5029
TCGA: ENSG00000175591
COSMIC: P2RY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175591ENST00000311131P41231
ENSG00000175591ENST00000393596P41231
ENSG00000175591ENST00000393597P41231

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Metabolism of proteinsREACTOMER-HSA-392499
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381417582024The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.0
381417582024The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.0
364694962023AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.3
369251962023Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.2
371659112023P2Y(2)R‑mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM‑1 overexpression in radiotherapy‑resistant‑triple negative breast cancer cells.0
364694962023AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.3
369251962023Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.2
371659112023P2Y(2)R‑mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM‑1 overexpression in radiotherapy‑resistant‑triple negative breast cancer cells.0
339110332021Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.4
343147352021Autocrine regulation of wound healing by ATP release and P2Y(2) receptor activation.7
346801362021Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.6
347695312021Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.0
339110332021Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.4
343147352021Autocrine regulation of wound healing by ATP release and P2Y(2) receptor activation.7
346801362021Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.6

Citation

Dessen P

P2RY2 (purinergic receptor P2Y2)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/41625/cancer-prone-explorer/favicon/js/web-card-gene.js