NUPR1 (nuclear protein 1, transcriptional regulator)

2003-06-01  

Identity

HGNC
NUPR1
LOCATION
16p11.2
LOCUSID
26471
ALIAS
COM1,P8

Other Information

Locus ID:

NCBI: 26471
MIM: 614812
HGNC: 29990
Ensembl: ENSG00000176046

Variants:

dbSNP: 26471
ClinVar: 26471
TCGA: ENSG00000176046
COSMIC: NUPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176046ENST00000324873O60356
ENSG00000176046ENST00000324873A0A024QZC4
ENSG00000176046ENST00000395641O60356
ENSG00000176046ENST00000567646H3BS92

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
374777582024WTAP Mediates NUPR1 Regulation of LCN2 Through m(6)A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.2
386530912024NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway.0
374777582024WTAP Mediates NUPR1 Regulation of LCN2 Through m(6)A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.2
386530912024NUPR1 induces autophagy and promotes the progression of Esophageal squamous cell carcinoma via the MAPK-mTOR pathway.0
364686532023NUPR1 imparts oncogenic potential in bladder cancer.7
375664782023Nuclear protein-1 is the common link for pathways activated by aging and obesity in chondrocytes: A potential therapeutic target for osteoarthritis.0
378077302023[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].0
378794292023SETD4 inhibits prostate cancer development by promoting H3K27me3-mediated NUPR1 transcriptional repression and cell cycle arrest.0
364686532023NUPR1 imparts oncogenic potential in bladder cancer.7
375664782023Nuclear protein-1 is the common link for pathways activated by aging and obesity in chondrocytes: A potential therapeutic target for osteoarthritis.0
378077302023[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].0
378794292023SETD4 inhibits prostate cancer development by promoting H3K27me3-mediated NUPR1 transcriptional repression and cell cycle arrest.0
353509072022Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression.3
354625762022NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy.24
356605382022NUPR1 promotes the proliferation and migration of breast cancer cells by activating TFE3 transcription to induce autophagy.9

Citation

Dessen P

NUPR1 (nuclear protein 1, transcriptional regulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41627