Identity
HGNC
LOCATION
9q33.1
LOCUSID
ALIAS
ASBABP2,DIPLA1,IGFBP-4ase,PAPA,PAPP-A,PAPPA1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5069
MIM: 176385
HGNC: 8602
Ensembl: ENSG00000182752
Variants:
dbSNP: 5069
ClinVar: 5069
TCGA: ENSG00000182752
COSMIC: PAPPA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182752 | ENST00000328252 | Q13219 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35971034 | 2023 | m(6)A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer. | 5 |
| 36549546 | 2023 | Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes. | 2 |
| 37062114 | 2023 | Associations between nausea and vomiting in pregnancy, disgust sensitivity, and first-trimester maternal serum free β-hCG and PAPP-A. | 1 |
| 37176126 | 2023 | PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. | 0 |
| 37267421 | 2023 | The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story. | 5 |
| 37916365 | 2023 | Elevated first-trimester PAPP-A is a marker in high-risk pregnancies with an increased risk of placenta accreta in predicting adverse outcomes. | 1 |
| 38082246 | 2023 | Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study. | 1 |
| 35971034 | 2023 | m(6)A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer. | 5 |
| 36549546 | 2023 | Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes. | 2 |
| 37062114 | 2023 | Associations between nausea and vomiting in pregnancy, disgust sensitivity, and first-trimester maternal serum free β-hCG and PAPP-A. | 1 |
| 37176126 | 2023 | PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. | 0 |
| 37267421 | 2023 | The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story. | 5 |
| 37916365 | 2023 | Elevated first-trimester PAPP-A is a marker in high-risk pregnancies with an increased risk of placenta accreta in predicting adverse outcomes. | 1 |
| 38082246 | 2023 | Correlation between PAPP-A serum levels in the first trimester of pregnancy with the occurrence of gestational diabetes, a multicenter cohort study. | 1 |
| 34350538 | 2022 | Pregnancy-associated plasma protein A mRNA expression as a marker for differentiated thyroid cancer: results from a "surgical" and a "cytological" series. | 1 |
Citation
Dessen P
PAPPA (pappalysin 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41637/pappa
