Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5078
MIM: 167413
HGNC: 8618
Ensembl: ENSG00000106331
Variants:
dbSNP: 5078
ClinVar: 5078
TCGA: ENSG00000106331
COSMIC: PAX4
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PD | ||
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PD | 24752311 | |
| PA451234 | repaglinide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451283 | rosiglitazone | Chemical | ClinicalAnnotation | associated | PD | 24752311 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37175989 | 2023 | Pax4 in Health and Diabetes. | 2 |
| 37777536 | 2023 | PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development. | 3 |
| 37175989 | 2023 | Pax4 in Health and Diabetes. | 2 |
| 37777536 | 2023 | PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development. | 3 |
| 35108381 | 2022 | Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY. | 13 |
| 35570489 | 2022 | Ethnic-Specific Type 2 Diabetes Risk Factor PAX4 R192H Is Associated with Attention-Specific Cognitive Impairment in Chinese with Type 2 Diabetes. | 0 |
| 35108381 | 2022 | Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY. | 13 |
| 35570489 | 2022 | Ethnic-Specific Type 2 Diabetes Risk Factor PAX4 R192H Is Associated with Attention-Specific Cognitive Impairment in Chinese with Type 2 Diabetes. | 0 |
| 34162761 | 2021 | Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis. | 2 |
| 34162761 | 2021 | Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis. | 2 |
| 33009794 | 2020 | [Alternative Variants of Pax4 Human Transcription Factor: Comparative Transcriptional Activity]. | 0 |
| 33009794 | 2020 | [Alternative Variants of Pax4 Human Transcription Factor: Comparative Transcriptional Activity]. | 0 |
| 28730907 | 2018 | The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women. | 1 |
| 29941447 | 2018 | Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population. | 21 |
| 28730907 | 2018 | The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women. | 1 |
Citation
Dessen P
PAX4 (paired box 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41643/pax4
