PDCD2 (programmed cell death 2)

2003-02-01  

Identity

HGNC
PDCD2
LOCATION
6q27
LOCUSID
5134
ALIAS
RP8,ZMYND7

Other Information

Locus ID:

NCBI: 5134
MIM: 600866
HGNC: 8762
Ensembl: ENSG00000071994

Variants:

dbSNP: 5134
ClinVar: 5134
TCGA: ENSG00000071994
COSMIC: PDCD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071994ENST00000167218J3QK82
ENSG00000071994ENST00000392090Q16342
ENSG00000071994ENST00000443345Q16342
ENSG00000071994ENST00000453163Q16342
ENSG00000071994ENST00000537445Q16342
ENSG00000071994ENST00000539212H0YFM2
ENSG00000071994ENST00000541970Q16342
ENSG00000071994ENST00000542896F5H4V9
ENSG00000071994ENST00000544336F5GWT2
ENSG00000071994ENST00000544755H0YFS8
ENSG00000071994ENST00000544866H0YFZ5
ENSG00000071994ENST00000545869F5GWT2
ENSG00000071994ENST00000614056A0A087WYJ3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
332457682020PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).11
332457682020PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).11
306641772019PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition.11
306641772019PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition.11
265899422016PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.13
265899422016PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.13
253340102015Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.12
266178042015Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.6
253340102015Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.12
266178042015Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.6
243811962014Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.16
251114612014miR-129-1-3p promote BGC-823 cell proliferation by targeting PDCD2.7
243811962014Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.16
251114612014miR-129-1-3p promote BGC-823 cell proliferation by targeting PDCD2.7
237604972013PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.18

Citation

Dessen P

PDCD2 (programmed cell death 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41674/js/deep-insight-explorer/haematological-explorer/