PDE10A (phosphodiesterase 10A)

2003-05-01  

Identity

HGNC
PDE10A
LOCATION
6q27
LOCUSID
10846
ALIAS
ADSD2,HSPDE10A,IOLOD,LINC00473,PDE10A19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10846
MIM: 610652
HGNC: 8772
Ensembl: ENSG00000112541

Variants:

dbSNP: 10846
ClinVar: 10846
TCGA: ENSG00000112541
COSMIC: PDE10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112541ENST00000366882Q9Y233
ENSG00000112541ENST00000539869A0A3F2YP58
ENSG00000112541ENST00000580695A0A3B3IU85
ENSG00000112541ENST00000616273A0A087WUD0
ENSG00000112541ENST00000647590A0A3B3IRU7
ENSG00000112541ENST00000647768A0A3B3ITT8
ENSG00000112541ENST00000647837A0A3B3IS50
ENSG00000112541ENST00000648884A0A1B1UZQ1
ENSG00000112541ENST00000648917A0A3B3ISJ6
ENSG00000112541ENST00000649247A0A3B3IT18
ENSG00000112541ENST00000649273A0A3B3IRL3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368055232023Expanding the genotype-phenotype landscape of PDE10A-associated movement disorders.0
368055232023Expanding the genotype-phenotype landscape of PDE10A-associated movement disorders.0
345503222022Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.2
363241872022Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer.7
345503222022Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.2
363241872022Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer.7
339081392021LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR-15a-5p/LITAF axis in pre-eclampsia.9
339142372021Papaverine, a Phosphodiesterase 10A Inhibitor, Ameliorates Quinolinic Acid-Induced Synaptotoxicity in Human Cortical Neurons.8
339081392021LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR-15a-5p/LITAF axis in pre-eclampsia.9
339142372021Papaverine, a Phosphodiesterase 10A Inhibitor, Ameliorates Quinolinic Acid-Induced Synaptotoxicity in Human Cortical Neurons.8
318711902020Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.4
321199132020Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.9
318711902020Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.4
321199132020Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.9
313159722019Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity.27

Citation

Dessen P

PDE10A (phosphodiesterase 10A)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41678/deep-insight-explorer/css/css/template-card.css