PDK2 (pyruvate dehydrogenase kinase 2)

2003-05-01  

Identity

HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
PDHK2,PDKII
FUSION GENES

Other Information

Locus ID:

NCBI: 5164
MIM: 602525
HGNC: 8810
Ensembl: ENSG00000005882

Variants:

dbSNP: 5164
ClinVar: 5164
TCGA: ENSG00000005882
COSMIC: PDK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005882ENST00000007708Q15119
ENSG00000005882ENST00000503176Q15119
ENSG00000005882ENST00000503614D6RDN9
ENSG00000005882ENST00000505440D6RJH7
ENSG00000005882ENST00000508030D6RHG2
ENSG00000005882ENST00000510219D6R983
ENSG00000005882ENST00000512238D6RGV8
ENSG00000005882ENST00000614357Q15119

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
337839042021Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis.9
344644822021PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma.14
337839042021Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis.9
344644822021PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma.14
305784122020Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia.22
332365962020[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].1
305784122020Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia.22
332365962020[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].1
304570212019PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3.11
304570212019PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3.11
297251302018MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer.36
297251302018MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer.36
281785232017The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism.36
281785232017The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism.36
266079042016Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer.41

Citation

Dessen P

PDK2 (pyruvate dehydrogenase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41683/img/css/teaching-explorer/