PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)

2003-11-01 Affiliation

Identity

HGNC

PIK3C3

LOCATION

18q12.3

LOCUSID

5289

ALIAS

VPS34,Vps34,hVps34

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5289
MIM: 602609
HGNC: 8974
Ensembl: ENSG00000078142

Variants:

dbSNP: 5289
ClinVar: 5289
TCGA: ENSG00000078142
COSMIC: PIK3C3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000078142	ENST00000262039	Q8NEB9
ENSG00000078142	ENST00000398870	A8MYT4
ENSG00000078142	ENST00000585528	K7EIV6
ENSG00000078142	ENST00000586545	K7EKH3
ENSG00000078142	ENST00000587402	M0R386
ENSG00000078142	ENST00000589056	A0A0B4J2B1
ENSG00000078142	ENST00000591011	K7ENH3
ENSG00000078142	ENST00000597477	M0R308
ENSG00000078142	ENST00000639914	A0A1W2PS05

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Phosphatidylinositol signaling system	KEGG	ko04070
Autophagy - animal	KEGG	ko04140
Inositol phosphate metabolism	KEGG	hsa00562
Phosphatidylinositol signaling system	KEGG	hsa04070
Autophagy - animal	KEGG	hsa04140
Metabolic pathways	KEGG	hsa01100
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate NADPH Oxidases	REACTOME	R-HSA-5668599
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the Golgi membrane	REACTOME	R-HSA-1660514
Synthesis of PIPs at the early endosome membrane	REACTOME	R-HSA-1660516
Synthesis of PIPs at the late endosome membrane	REACTOME	R-HSA-1660517
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Apelin signaling pathway	KEGG	hsa04371
Autophagy - other	KEGG	ko04136
Autophagy - other	KEGG	hsa04136

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36629752	2023	PIK3C3/VPS34 keeps body fats healthy.	0
36656016	2023	Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.	1
37267363	2023	ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.	9
36629752	2023	PIK3C3/VPS34 keeps body fats healthy.	0
36656016	2023	Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.	1
37267363	2023	ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.	9
34870550	2022	Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.	6
35333349	2022	Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss.	2
34870550	2022	Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers.	6
35333349	2022	Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss.	2
32248620	2021	The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I.	12
33400087	2021	Targeting the Autophagy Specific Lipid Kinase VPS34 for Cancer Treatment: An Integrative Repurposing Strategy.	1
33637724	2021	VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.	26
33664238	2021	SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer.	41
33692360	2021	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.	31

Citation

Dessen P

PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41714