PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

2003-02-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
PI3CG,PI3K,PI3Kgamma,PIK3,p110gamma,p120-PI3K

Other Information

Locus ID:

NCBI: 5294
MIM: 601232
HGNC: 8978
Ensembl: ENSG00000105851

Variants:

dbSNP: 5294
ClinVar: 5294
TCGA: ENSG00000105851
COSMIC: PIK3CG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105851ENST00000359195P48736
ENSG00000105851ENST00000359195A0A024R720
ENSG00000105851ENST00000440650P48736
ENSG00000105851ENST00000440650A0A024R720
ENSG00000105851ENST00000473541E9PDN7
ENSG00000105851ENST00000496166P48736
ENSG00000105851ENST00000496166A0A024R720

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Inositol phosphate metabolismKEGGhsa00562
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Cholinergic synapseKEGGhsa04725
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24684AKT1GenePathwayassociated28362716
PA27844ERBB2GenePathwayassociated
PA27846ERBB3GenePathwayassociated
PA27847ERBB4GenePathwayassociated
PA28180FLT1GenePathwayassociated28362716
PA28183FLT4GenePathwayassociated28362716
PA30086KDRGenePathwayassociated28362716
PA7360EGFRGenePathwayassociated

References

Pubmed IDYearTitleCitations
382716602024PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.1
382716602024PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.1
367793492023Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.2
367793492023Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.2
353535412022A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.4
356737792022High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.0
357258902022PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.0
358702622022Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.0
353535412022A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.4
356737792022High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.0
357258902022PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.0
358702622022Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.0
333019892021Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.1
334935142021G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.9
335398762021Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.2

Citation

Dessen P

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41716/cancer-prone-explorer/js/lib/favicon/favicon-16x16.png