PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

2003-02-01 Affiliation

Identity

HGNC

PIK3CG

LOCATION

7q22.3

LOCUSID

5294

ALIAS

PI3CG,PI3K,PI3Kgamma,PIK3,p110gamma,p120-PI3K

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5294
MIM: 601232
HGNC: 8978
Ensembl: ENSG00000105851

Variants:

dbSNP: 5294
ClinVar: 5294
TCGA: ENSG00000105851
COSMIC: PIK3CG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105851	ENST00000359195	P48736
ENSG00000105851	ENST00000359195	A0A024R720
ENSG00000105851	ENST00000440650	P48736
ENSG00000105851	ENST00000440650	A0A024R720
ENSG00000105851	ENST00000473541	E9PDN7
ENSG00000105851	ENST00000496166	P48736
ENSG00000105851	ENST00000496166	A0A024R720

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Inositol phosphate metabolism	KEGG	hsa00562
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Cholinergic synapse	KEGG	hsa04725
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G-protein beta:gamma signalling	REACTOME	R-HSA-397795
G beta:gamma signalling through PI3Kgamma	REACTOME	R-HSA-392451
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA24684	AKT1	Gene	Pathway	associated	28362716
PA27844	ERBB2	Gene	Pathway	associated
PA27846	ERBB3	Gene	Pathway	associated
PA27847	ERBB4	Gene	Pathway	associated
PA28180	FLT1	Gene	Pathway	associated	28362716
PA28183	FLT4	Gene	Pathway	associated	28362716
PA30086	KDR	Gene	Pathway	associated	28362716
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38271660	2024	PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.	1
38271660	2024	PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.	1
36779349	2023	Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.	2
36779349	2023	Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.	2
35353541	2022	A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.	4
35673779	2022	High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.	0
35725890	2022	PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.	0
35870262	2022	Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.	0
35353541	2022	A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.	4
35673779	2022	High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.	0
35725890	2022	PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.	0
35870262	2022	Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.	0
33301989	2021	Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.	1
33493514	2021	G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.	9
33539876	2021	Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.	2

Citation

Dessen P

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41716/case-report-explorer/img/haematological-explorer/