PIR (pirin)

2003-05-01  

Identity

HGNC
PIR
LOCATION
Xp22.2
LOCUSID
8544

Other Information

Locus ID:

NCBI: 8544
MIM: 300931
HGNC: 30048
Ensembl: ENSG00000087842

Variants:

dbSNP: 8544
ClinVar: 8544
TCGA: ENSG00000087842
COSMIC: PIR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087842ENST00000380420O00625
ENSG00000087842ENST00000380420A0A024RBX6
ENSG00000087842ENST00000380421O00625
ENSG00000087842ENST00000380421A0A024RBX6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
333738532021Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis.22
333896782021PIWIL1 interacting RNA piR-017061 inhibits pancreatic cancer growth via regulating EFNA5.13
333738532021Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis.22
333896782021PIWIL1 interacting RNA piR-017061 inhibits pancreatic cancer growth via regulating EFNA5.13
304440382019Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p.20
315005132019PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.9
304440382019Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p.20
315005132019PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.9
288252942017Redox-Specific Allosteric Modulation of the Conformational Dynamics of κB DNA by Pirin in the NF-κB Supramolecular Complex.4
288252942017Redox-Specific Allosteric Modulation of the Conformational Dynamics of κB DNA by Pirin in the NF-κB Supramolecular Complex.4
256805272015Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.20
256805272015Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.20
242728842014Pirin down-regulates the EAF2/U19 protein and alleviates its growth inhibition in prostate cancer cells.7
243900862014Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element.16
242728842014Pirin down-regulates the EAF2/U19 protein and alleviates its growth inhibition in prostate cancer cells.7

Citation

Dessen P

PIR (pirin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41722/deep-insight-explorer/meetings/