PLA2G2D (phospholipase A2 group IID)

2003-05-01 Affiliation

Identity

HGNC

PLA2G2D

LOCATION

1p36.12

LOCUSID

26279

ALIAS

PLA2IID,SPLASH,sPLA2-IID,sPLA2S

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26279
MIM: 605630
HGNC: 9033
Ensembl: ENSG00000117215

Variants:

dbSNP: 26279
ClinVar: 26279
TCGA: ENSG00000117215
COSMIC: PLA2G2D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117215	ENST00000375105	Q9UNK4
ENSG00000117215	ENST00000617227	A0A087WZT4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Ether lipid metabolism	KEGG	ko00565
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
alpha-Linolenic acid metabolism	KEGG	ko00592
Glycerophospholipid metabolism	KEGG	hsa00564
Ether lipid metabolism	KEGG	hsa00565
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
alpha-Linolenic acid metabolism	KEGG	hsa00592
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Metabolic pathways	KEGG	hsa01100
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Fat digestion and absorption	KEGG	ko04975
Fat digestion and absorption	KEGG	hsa04975
Ras signaling pathway	KEGG	hsa04014
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801
Acyl chain remodelling of PI	REACTOME	R-HSA-1482922
Acyl chain remodelling of PG	REACTOME	R-HSA-1482925

References

Pubmed ID	Year	Title	Citations
26392224	2015	Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.	87
26392224	2015	Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.	87
22240557	2012	Secretory phospholipase A2 group IID Is involved in progesterone-induced acrosomal exocytosis of human spermatozoa.	5
22490726	2012	The bactericidal effect of human secreted group IID phospholipase A2 results from both hydrolytic and non-hydrolytic activities.	1
22240557	2012	Secretory phospholipase A2 group IID Is involved in progesterone-induced acrosomal exocytosis of human spermatozoa.	5
22490726	2012	The bactericidal effect of human secreted group IID phospholipase A2 results from both hydrolytic and non-hydrolytic activities.	1
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	6
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	6
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
19365107	2009	Gly80Ser polymorphism of phospholipase A2-IID is associated with cytokine inducibility in A549 cells.	6
19365107	2009	Gly80Ser polymorphism of phospholipase A2-IID is associated with cytokine inducibility in A549 cells.	6
18958346	2008	Destabilization of acrosome and elastase influence mediate the release of secretory phospholipase A2 from human spermatozoa.	2
18958346	2008	Destabilization of acrosome and elastase influence mediate the release of secretory phospholipase A2 from human spermatozoa.	2
16002569	2005	A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease.	12

Citation

Dessen P

PLA2G2D (phospholipase A2 group IID)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41731