Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA (EMP)
PLK1 has also been linked to known pathways that are altered during the neoplastic transformation. Retinoblastoma tumor suppressor (RB) pathway activation results in the repression of PLK1 promoter in a SWI/SNF chromatin remodeling complex dependent manner. In case of RB inactivation, PLK1 expression seems to be deregulated. This new finding suggests that PLK1 may be a target of the retinoblastoma tumor suppressor (RB) pathway.
Moreover, PLK1 seems to be involved in the tumor suppressor p53 related pathways. Evidence suggests that PLK1 can inhibit transactivation and pro-apoptotic functions of p53 function by physical interaction and phosphorylation.
In addition to PLK1s role in normal cell cycle regulation, its connection to such known tumor suppressors may be crucial for the tumorigenesis processes.
Ayse Elif Erson ; Elizabeth M. Petty
PLK1 (polo-like kinase 1 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2005-04-01
Online version: http://atlasgeneticsoncology.org/gene/41747/plk1-(polo-like-kinase-1-(drosophila))