PLXDC1 (plexin domain containing 1)

2003-06-01  

Identity

HGNC
PLXDC1
LOCATION
17q12
LOCUSID
57125
ALIAS
TEM3,TEM7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57125
MIM: 606826
HGNC: 20945
Ensembl: ENSG00000161381

Variants:

dbSNP: 57125
ClinVar: 57125
TCGA: ENSG00000161381
COSMIC: PLXDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161381ENST00000315392Q8IUK5
ENSG00000161381ENST00000415163C9JCL2
ENSG00000161381ENST00000441877C9JWQ3
ENSG00000161381ENST00000444911B4E173
ENSG00000161381ENST00000578390Q8IUK5
ENSG00000161381ENST00000578808J3KS04
ENSG00000161381ENST00000579190J3QR40
ENSG00000161381ENST00000579279J3QRR7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336571662021Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV).5
336571662021Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV).5
304141872019Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1.18
313522222019Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.5
304141872019Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1.18
313522222019Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.5
298908522018Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer.24
298908522018Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer.24
260930872015The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis.34
260930872015The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis.34
255358412014Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.38
255358412014Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.38
219585272011Tumor endothelial marker 7 (TEM-7): a novel target for antiangiogenic therapy.14
219585272011Tumor endothelial marker 7 (TEM-7): a novel target for antiangiogenic therapy.14
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

PLXDC1 (plexin domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41752/css/deep-insight-explorer/js/lib/all.min.js