POLB (DNA polymerase beta)

2003-02-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5423
MIM: 174760
HGNC: 9174
Ensembl: ENSG00000070501

Variants:

dbSNP: 5423
ClinVar: 5423
TCGA: ENSG00000070501
COSMIC: POLB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070501ENST00000265421P06746
ENSG00000070501ENST00000517393H0YAV8
ENSG00000070501ENST00000518579H0YBX1
ENSG00000070501ENST00000518925E7EW18
ENSG00000070501ENST00000519771E5RG65
ENSG00000070501ENST00000520008E5RJ55
ENSG00000070501ENST00000521290H0YBJ0
ENSG00000070501ENST00000521492E5RHZ4
ENSG00000070501ENST00000522610E5RIJ0
ENSG00000070501ENST00000524208H0YB29
ENSG00000070501ENST00000532157E9PIC6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
BER complexKEGGhsa_M00296
BER complexKEGGM00296
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the single-nucleotide replacement pathwayREACTOMER-HSA-110381
Abasic sugar-phosphate removal via the single-nucleotide replacement pathwayREACTOMER-HSA-73930
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
POLB-Dependent Long Patch Base Excision RepairREACTOMER-HSA-110362
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
238276802013Observing a DNA polymerase choose right from wrong.97
184719772008Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.78
125173462003Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential.75
183133852008CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.74
166090222006Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.71
155617062005DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.66
175267402007The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.62
172095562007Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.56
123701692002Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.53

Citation

Dessen P

POLB (DNA polymerase beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41769/polb-(dna-polymerase-beta)