POLI (DNA polymerase iota)

2003-02-01  

Identity

HGNC
POLI
LOCATION
18q21.2
LOCUSID
11201
ALIAS
RAD30B,RAD3OB,eta2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11201
MIM: 605252
HGNC: 9182
Ensembl: ENSG00000101751

Variants:

dbSNP: 11201
ClinVar: 11201
TCGA: ENSG00000101751
COSMIC: POLI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101751ENST00000217800X6R2I3
ENSG00000101751ENST00000406285J3KQ09
ENSG00000101751ENST00000577612J3QR36
ENSG00000101751ENST00000579434J3KSW2
ENSG00000101751ENST00000579534Q9UNA4
ENSG00000101751ENST00000579823J3KTM8
ENSG00000101751ENST00000580880J3KRG0
ENSG00000101751ENST00000581950J3KRS8
ENSG00000101751ENST00000583136J3KTN3
ENSG00000101751ENST00000585023J3QQZ8

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by POLIREACTOMER-HSA-5656121
Termination of translesion DNA synthesisREACTOMER-HSA-5656169

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341655732021Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.7
346457852021p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.8
341655732021Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.7
346457852021p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.8
318055012020Polymerase iota - an odd sibling among Y family polymerases.21
326357232020Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H(2)O(2) Sensitivity in POLI-Deficient Cells.3
330872802020Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.4
331663982020Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.12
333762202020DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.10
318055012020Polymerase iota - an odd sibling among Y family polymerases.21
326357232020Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H(2)O(2) Sensitivity in POLI-Deficient Cells.3
330872802020Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.4
331663982020Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.12
333762202020DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.10
308296102019DNA polymerase iota (Pol ι) promotes the migration and invasion of breast cancer cell via EGFR-ERK-mediated epithelial to mesenchymal transition.4

Citation

Dessen P

POLI (DNA polymerase iota)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41776