POLK (DNA polymerase kappa)

2004-04-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
DINB1,DINP,POLQ

Other Information

Locus ID:

NCBI: 51426
MIM: 605650
HGNC: 9183
Ensembl: ENSG00000122008

Variants:

dbSNP: 51426
ClinVar: 51426
TCGA: ENSG00000122008
COSMIC: POLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122008ENST00000241436Q9UBT6
ENSG00000122008ENST00000241436A0A024RAP4
ENSG00000122008ENST00000503479D6RAE5
ENSG00000122008ENST00000504026Q9UBT6
ENSG00000122008ENST00000505774D6RAI7
ENSG00000122008ENST00000505975D6RAI7
ENSG00000122008ENST00000508526Q9UBT6
ENSG00000122008ENST00000509126Q9UBT6
ENSG00000122008ENST00000510815Q9UBT6
ENSG00000122008ENST00000511527D6RAI7
ENSG00000122008ENST00000514141D6R9M8
ENSG00000122008ENST00000514296D6RDX9
ENSG00000122008ENST00000515295Q9UBT6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by POLKREACTOMER-HSA-5655862
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

References

Pubmed IDYearTitleCitations
387179692024Effects of the Y432S Cancer-Associated Variant on the Reaction Mechanism of Human DNA Polymerase κ.0
387179692024Effects of the Y432S Cancer-Associated Variant on the Reaction Mechanism of Human DNA Polymerase κ.0
378837882023Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties.0
378837882023Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties.0
350890322022Miscoding and DNA Polymerase Stalling by Methoxyamine-Adducted Abasic Sites.4
350890322022Miscoding and DNA Polymerase Stalling by Methoxyamine-Adducted Abasic Sites.4
344611012021DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.3
346671552021Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA.15
344611012021DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.3
346671552021Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA.15
323457252020Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance.19
327218182020Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells.0
323457252020Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance.19
327218182020Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells.0
308621402019[Genetic variation in DNA polymerase kappa gene is associated with the prognosis after platinum-based chemotherapy in small cell lung cancer patients].1

Citation

Dessen P

POLK (DNA polymerase kappa)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41777/polk