POLL (DNA polymerase lambda)

2004-04-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
BETAN,POLKAPPA

Other Information

Locus ID:

NCBI: 27343
MIM: 606343
HGNC: 9184
Ensembl: ENSG00000166169

Variants:

dbSNP: 27343
ClinVar: 27343
TCGA: ENSG00000166169
COSMIC: POLL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166169ENST00000299206Q9UGP5
ENSG00000166169ENST00000339310Q5JQP4
ENSG00000166169ENST00000370162Q9UGP5
ENSG00000166169ENST00000370168Q9HBN3
ENSG00000166169ENST00000370169Q9UGP5
ENSG00000166169ENST00000370172Q5JQP8
ENSG00000166169ENST00000413344Q5JQP1
ENSG00000166169ENST00000415897Q5JQP2
ENSG00000166169ENST00000426919Q5JQN9
ENSG00000166169ENST00000429502Q5JQP3
ENSG00000166169ENST00000430045Q5JQP0
ENSG00000166169ENST00000454524Q5JQP7
ENSG00000166169ENST00000628479Q9UGP5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Non-homologous end-joiningKEGGko03450
Base excision repairKEGGhsa03410
Non-homologous end-joiningKEGGhsa03450
BER complexKEGGhsa_M00296
BER complexKEGGM00296
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
376974362023Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.0
376974362023Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.0
336734242021A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.3
336734242021A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.3
302500672018PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.16
302500672018PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.16
281097432017Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.9
288413052017Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.8
281097432017Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.9
288413052017Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.8
269171112016Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.23
274819342016A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.17
276212672016Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.8
279921862016Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.7
269171112016Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.23

Citation

Dessen P

POLL (DNA polymerase lambda)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41778/poll