POLR1B (RNA polymerase I subunit B)

2003-12-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
A135,RPA135,RPA2,Rpo1-2,TCS4
FUSION GENES

Other Information

Locus ID:

NCBI: 84172
MIM: 602000
HGNC: 20454
Ensembl: ENSG00000125630

Variants:

dbSNP: 84172
ClinVar: 84172
TCGA: ENSG00000125630
COSMIC: POLR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125630ENST00000263331Q9H9Y6
ENSG00000125630ENST00000333990F8WAK7
ENSG00000125630ENST00000409894Q9H9Y6
ENSG00000125630ENST00000417433Q9H9Y6
ENSG00000125630ENST00000424062F8WBB9
ENSG00000125630ENST00000430293F8WDS4
ENSG00000125630ENST00000430769C9JJG2
ENSG00000125630ENST00000438748C9JS83
ENSG00000125630ENST00000448770F8WCS3
ENSG00000125630ENST00000458012H7C0D9
ENSG00000125630ENST00000537335Q9H9Y6
ENSG00000125630ENST00000541869Q9H9Y6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
RNA polymeraseKEGGko03020
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
RNA polymeraseKEGGhsa03020
Metabolic pathwaysKEGGhsa01100
RNA polymerase I, eukaryotesKEGGhsa_M00182
RNA polymerase I, eukaryotesKEGGM00182
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

References

Pubmed IDYearTitleCitations
371673372023Expression of RNA polymerase I catalytic core is influenced by RPA12.1
371673372023Expression of RNA polymerase I catalytic core is influenced by RPA12.1
316492762020POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.37
316492762020POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.37
181946632008Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.0
181946632008Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.0
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.79
168805082006Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.24
168805082006Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.24
160557042005PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.57
160557042005PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.57

Citation

Dessen P

POLR1B (RNA polymerase I subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41780/polr1b