POR (cytochrome p450 oxidoreductase)

2003-08-01  

Identity

HGNC
POR
LOCATION
7q11.23
LOCUSID
5447
ALIAS
CPR,CYPOR,P450R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5447
MIM: 124015
HGNC: 9208
Ensembl: ENSG00000127948

Variants:

dbSNP: 5447
ClinVar: 5447
TCGA: ENSG00000127948
COSMIC: POR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127948ENST00000394893P16435
ENSG00000127948ENST00000412064P16435
ENSG00000127948ENST00000412521P16435
ENSG00000127948ENST00000414186P16435
ENSG00000127948ENST00000418341P16435
ENSG00000127948ENST00000421059C9JQ78
ENSG00000127948ENST00000426184C9JU80
ENSG00000127948ENST00000432753P16435
ENSG00000127948ENST00000439269E7EMD0
ENSG00000127948ENST00000439297C9JDE2
ENSG00000127948ENST00000439963P16435
ENSG00000127948ENST00000447222H0Y4R2
ENSG00000127948ENST00000448410E7EWU0
ENSG00000127948ENST00000449920P16435
ENSG00000127948ENST00000453773P16435
ENSG00000127948ENST00000454934P16435
ENSG00000127948ENST00000461988P16435

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD28117434
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD28117434
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD21770725, 23097010, 23974086, 24061445, 24113216, 24658827, 24739669, 24921414, 25271728, 25322286, 26227094, 26829596, 28094348, 29135906, 29399716, 29878980, 30323313
PA166114942familial hypercholesterolemiaDiseaseClinicalAnnotationassociatedPD25521355
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD25521355
PA449167cyclosporineChemicalClinicalAnnotationassociatedPK24061445, 24658827, 29135906
PA450496midazolamChemicalClinicalAnnotationassociatedPK19801957, 23324807
PA450626nicotineChemicalClinicalAnnotationassociatedPK
PA451365sirolimusChemicalClinicalAnnotationassociatedPK23974086
PA451578tacrolimusChemicalClinicalAnnotationassociatedPKPD21770725, 23097010, 24061445, 24113216, 24739669, 24921414, 25271728, 25322286, 26227094, 26829596, 28094348, 29399716, 29878980, 30323313
PA451906warfarinChemicalClinicalAnnotation, VariantAnnotationambiguousPD27488389
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
363214152023POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.1
369519642023Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.0
375091192023Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism.3
375176922023Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.1
363214152023POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.1
369519642023Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.0
375091192023Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism.3
375176922023Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.1
351647912022The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics.3
358895192022In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase.0
351647912022The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics.3
358895192022In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase.0
330118822021Microsomal reductase activity in patients with thyroid neoplasms.5
333210932021Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.182
334204182021An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase.10

Citation

Dessen P

POR (cytochrome p450 oxidoreductase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41787/js/js/lib/img/logo-atlas-4.svg