PPARA (peroxisome proliferator activated receptor alpha)

2003-08-01 Affiliation

Identity

HGNC

PPARA

LOCATION

22q13.31

LOCUSID

5465

ALIAS

NR1C1,PPAR,PPAR-alpha,PPARalpha,hPPAR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5465
MIM: 170998
HGNC: 9232
Ensembl: ENSG00000186951

Variants:

dbSNP: 5465
ClinVar: 5465
TCGA: ENSG00000186951
COSMIC: PPARA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186951	ENST00000262735	Q07869
ENSG00000186951	ENST00000262735	F1D8S4
ENSG00000186951	ENST00000402126	Q07869
ENSG00000186951	ENST00000402126	F1D8S4
ENSG00000186951	ENST00000407236	Q07869
ENSG00000186951	ENST00000407236	F1D8S4
ENSG00000186951	ENST00000415785	B0QYX2
ENSG00000186951	ENST00000420804	B0QYX1
ENSG00000186951	ENST00000440343	Q86SF0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
Adipocytokine signaling pathway	KEGG	ko04920
PPAR signaling pathway	KEGG	hsa03320
Adipocytokine signaling pathway	KEGG	hsa04920
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Transcriptional activation of mitochondrial biogenesis	REACTOME	R-HSA-2151201
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Nuclear Receptor transcription pathway	REACTOME	R-HSA-383280
YAP1- and WWTR1 (TAZ)-stimulated gene expression	REACTOME	R-HSA-2032785
Circadian Clock	REACTOME	R-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expression	REACTOME	R-HSA-1368108
RORA activates gene expression	REACTOME	R-HSA-1368082
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)	REACTOME	R-HSA-1655829
Activation of gene expression by SREBF (SREBP)	REACTOME	R-HSA-2426168
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA133888799	Organ Transplantation	Disease	ClinicalAnnotation	associated	PK		24658827
PA162370415	Metabolic Syndrome	Disease	VariantAnnotation	not associated		PD
PA164712535	Beta Blocking Agents	Chemical	ClinicalAnnotation	associated		PD	18855529
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated		PD	24113216, 29399716
PA443797	Coronary Disease	Disease	ClinicalAnnotation	associated		PD	18855529
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated		PD	15608561, 24853734
PA447216	Schizophrenia	Disease	VariantAnnotation	not associated		PD
PA449061	clozapine	Chemical	VariantAnnotation	not associated		PD
PA449594	fenofibrate	Chemical	ClinicalAnnotation	associated		PD	15608561
PA450395	metformin	Chemical	ClinicalAnnotation	associated		PD	24853734
PA450921	phenprocoumon	Chemical	ClinicalAnnotation	associated		PD	25461249
PA451363	simvastatin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation	associated		PD	23252946, 23930676, 24598718
PA451578	tacrolimus	Chemical	ClinicalAnnotation	associated	PK	PD	24113216, 24658827, 29399716

References

Pubmed ID	Year	Title	Citations
37926201	2024	The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.	0
38167146	2024	Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury.	0
39000217	2024	Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy.	0
37926201	2024	The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.	0
38167146	2024	Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury.	0
39000217	2024	Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy.	0
35459765	2023	Association of placental PPARα/γ and miR-27b expression with macrosomia in healthy pregnancy.	1
35460276	2023	Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis.	31
36305579	2023	Therapeutic roles of PPARα activation in ocular ischemic diseases.	4
36626642	2023	Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.	4
36812713	2023	The emerging role of PPAR-alpha in breast cancer.	4
37204637	2023	miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome.	0
37286039	2023	Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.	2
37482742	2023	[Preliminary study of PPARA regulate the ferroptosis of hepatocellular carcinoma to prevent disease deterioration].	0
37805161	2023	MiR-455-3p mediates PPARα through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells.	0

Citation

Dessen P

PPARA (peroxisome proliferator activated receptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41792/ppara