PPIE (peptidylprolyl isomerase E)

2003-02-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
CYP-33,CYP33
FUSION GENES

Other Information

Locus ID:

NCBI: 10450
MIM: 602435
HGNC: 9258
Ensembl: ENSG00000084072

Variants:

dbSNP: 10450
ClinVar: 10450
TCGA: ENSG00000084072
COSMIC: PPIE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000084072ENST00000324379Q9UNP9
ENSG00000084072ENST00000356511Q9UNP9
ENSG00000084072ENST00000372830Q9UNP9
ENSG00000084072ENST00000372835E9PEQ6
ENSG00000084072ENST00000470018E9PIB0
ENSG00000084072ENST00000470213E9PK21
ENSG00000084072ENST00000474804H0YCV4
ENSG00000084072ENST00000475350H0YE31
ENSG00000084072ENST00000495526E9PMH0
ENSG00000084072ENST00000497370E9PKY5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, 35S U5-snRNPKEGGM00355
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370751252023RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.0
370751252023RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.0
336066792021Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro.1
336066792021Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro.1
303899532018Comprehensive Analysis of Gene Expression Profiles and DNA Methylome reveals Oas1, Ppie, Polr2g as Pathogenic Target Genes of Gestational Diabetes Mellitus.8
303899532018Comprehensive Analysis of Gene Expression Profiles and DNA Methylome reveals Oas1, Ppie, Polr2g as Pathogenic Target Genes of Gestational Diabetes Mellitus.8
218872202011Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex.18
218872202011Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex.18
204601312010Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.25
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42
205412512010Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.105
206778322010The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .38
204601312010Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.25
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42
205412512010Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.105

Citation

Dessen P

PPIE (peptidylprolyl isomerase E)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41799/gene-fusions-explorer/gene-fusions/haematological-explorer/