Identity
HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
PP-1A,PP1A,PP1alpha,PPP1A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5499
MIM: 176875
HGNC: 9281
Ensembl: ENSG00000172531
Variants:
dbSNP: 5499
ClinVar: 5499
TCGA: ENSG00000172531
COSMIC: PPP1CA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33639 | PPP1R1B | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38057879 | 2023 | CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation. | 1 |
| 38057879 | 2023 | CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation. | 1 |
| 34964699 | 2022 | Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer. | 8 |
| 34964699 | 2022 | Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer. | 8 |
| 33675985 | 2021 | LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction. | 14 |
| 33941854 | 2021 | Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1α. | 16 |
| 34100859 | 2021 | Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions. | 5 |
| 34260925 | 2021 | Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. | 9 |
| 33675985 | 2021 | LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction. | 14 |
| 33941854 | 2021 | Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1α. | 16 |
| 34100859 | 2021 | Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions. | 5 |
| 34260925 | 2021 | Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. | 9 |
| 32585168 | 2020 | Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211. | 2 |
| 32681005 | 2020 | Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. | 22 |
| 33058883 | 2020 | Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters. | 15 |
Citation
Dessen P
PPP1CA (protein phosphatase 1 catalytic subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41804/ppp1ca
