PPP1CC (protein phosphatase 1 catalytic subunit gamma)

2003-11-01  

Identity

HGNC
PPP1CC
LOCATION
12q24.11
LOCUSID
5501
ALIAS
PP-1G,PP1C,PPP1G
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5501
MIM: 176914
HGNC: 9283
Ensembl: ENSG00000186298

Variants:

dbSNP: 5501
ClinVar: 5501
TCGA: ENSG00000186298
COSMIC: PPP1CC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186298ENST00000335007P36873
ENSG00000186298ENST00000335007A0A024RBP2
ENSG00000186298ENST00000340766P36873
ENSG00000186298ENST00000546933F8W0W8
ENSG00000186298ENST00000550261F8W0V8
ENSG00000186298ENST00000550991F8VYE8
ENSG00000186298ENST00000551582F8W1A0
ENSG00000186298ENST00000551676F8VR82
ENSG00000186298ENST00000620030A0A087WYY5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Long-term potentiationKEGGko04720
Regulation of actin cytoskeletonKEGGko04810
Insulin signaling pathwayKEGGko04910
Focal adhesionKEGGhsa04510
Long-term potentiationKEGGhsa04720
Regulation of actin cytoskeletonKEGGhsa04810
Insulin signaling pathwayKEGGhsa04910
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Circadian ClockREACTOMER-HSA-400253
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
385894962024High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma.0
385894962024High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma.0
370858152023PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.0
381391892023TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation.1
370858152023PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.0
381391892023TIMAP, a Regulatory Subunit of Protein Phosphatase 1, Inhibits In Vitro Neuronal Differentiation.1
358308822022Structure of the MRAS-SHOC2-PP1C phosphatase complex.7
358315092022Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.19
361756702022Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.11
358308822022Structure of the MRAS-SHOC2-PP1C phosphatase complex.7
358315092022Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.19
361756702022Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.11
336394012021The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.8
336394012021The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.8
329387142020Aurora B regulates PP1γ-Repo-Man interactions to maintain the chromosome condensation state.1

Citation

Dessen P

PPP1CC (protein phosphatase 1 catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41806