PPP3CA (protein phosphatase 3 catalytic subunit alpha)

2003-11-01  

Identity

HGNC
PPP3CA
LOCATION
4q24
LOCUSID
5530
ALIAS
ACCIID,CALN,CALNA,CALNA1,CCN1,CNA1,DEE91,IECEE,IECEE1,PPP2B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5530
MIM: 114105
HGNC: 9314
Ensembl: ENSG00000138814

Variants:

dbSNP: 5530
ClinVar: 5530
TCGA: ENSG00000138814
COSMIC: PPP3CA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138814ENST00000323055Q08209
ENSG00000138814ENST00000394853Q08209
ENSG00000138814ENST00000394853A0A0S2Z4B5
ENSG00000138814ENST00000394854Q08209
ENSG00000138814ENST00000394854A0A0S2Z4C6
ENSG00000138814ENST00000492351H0YAB4
ENSG00000138814ENST00000507176E7ETC2
ENSG00000138814ENST00000512215Q08209
ENSG00000138814ENST00000525819E9PPC8
ENSG00000138814ENST00000529324E9PK68

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Calcium signaling pathwayKEGGko04020
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
VEGF signaling pathwayKEGGko04370
Natural killer cell mediated cytotoxicityKEGGko04650
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
Long-term potentiationKEGGko04720
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Calcium signaling pathwayKEGGhsa04020
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
VEGF signaling pathwayKEGGhsa04370
Natural killer cell mediated cytotoxicityKEGGhsa04650
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
Long-term potentiationKEGGhsa04720
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activationREACTOMER-HSA-5607763
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165817016Kidney TransplantationDiseaseVariantAnnotationnot associatedPD
PA248NFKB1GenePathwayassociated23922006
PA296RELAGenePathwayassociated23922006
PA31582NFATC1GenePathwayassociated23922006
PA31583NFATC2GenePathwayassociated23922006
PA31584NFATC4GenePathwayassociated23922006
PA31600NFKB2GenePathwayassociated23922006
PA34321RELGenePathwayassociated23922006
PA34322RELBGenePathwayassociated23922006
PA451578tacrolimusChemicalVariantAnnotationnot associatedPD

References

Pubmed IDYearTitleCitations
365259282023Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability.3
365259282023Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability.3
353245242022TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.6
353245242022TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.6
339637602021PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy.7
347116832021Calcineurin regulates the stability and activity of estrogen receptor α.11
347956762021Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?2
339637602021PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy.7
347116832021Calcineurin regulates the stability and activity of estrogen receptor α.11
347956762021Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?2
324224332020Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin.2
328592152020Calcineurin.62
324224332020Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin.2
328592152020Calcineurin.62
302542152019Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.20

Citation

Dessen P

PPP3CA (protein phosphatase 3 catalytic subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41822/ppp3ca-(protein-phosphatase-3-catalytic-subunit-alpha)