PPP3CA (protein phosphatase 3 catalytic subunit alpha)

2003-11-01 Affiliation

Identity

HGNC

PPP3CA

LOCATION

4q24

LOCUSID

5530

ALIAS

ACCIID,CALN,CALNA,CALNA1,CCN1,CNA1,DEE91,IECEE,IECEE1,PPP2B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5530
MIM: 114105
HGNC: 9314
Ensembl: ENSG00000138814

Variants:

dbSNP: 5530
ClinVar: 5530
TCGA: ENSG00000138814
COSMIC: PPP3CA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138814	ENST00000323055	Q08209
ENSG00000138814	ENST00000394853	Q08209
ENSG00000138814	ENST00000394853	A0A0S2Z4B5
ENSG00000138814	ENST00000394854	Q08209
ENSG00000138814	ENST00000394854	A0A0S2Z4C6
ENSG00000138814	ENST00000492351	H0YAB4
ENSG00000138814	ENST00000507176	E7ETC2
ENSG00000138814	ENST00000512215	Q08209
ENSG00000138814	ENST00000525819	E9PPC8
ENSG00000138814	ENST00000529324	E9PK68

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Calcium signaling pathway	KEGG	ko04020
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Long-term potentiation	KEGG	ko04720
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Calcium signaling pathway	KEGG	hsa04020
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Long-term potentiation	KEGG	hsa04720
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activation	REACTOME	R-HSA-5607763
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
DARPP-32 events	REACTOME	R-HSA-180024
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA165817016	Kidney Transplantation	Disease	VariantAnnotation	not associated	PD
PA248	NFKB1	Gene	Pathway	associated		23922006
PA296	RELA	Gene	Pathway	associated		23922006
PA31582	NFATC1	Gene	Pathway	associated		23922006
PA31583	NFATC2	Gene	Pathway	associated		23922006
PA31584	NFATC4	Gene	Pathway	associated		23922006
PA31600	NFKB2	Gene	Pathway	associated		23922006
PA34321	REL	Gene	Pathway	associated		23922006
PA34322	RELB	Gene	Pathway	associated		23922006
PA451578	tacrolimus	Chemical	VariantAnnotation	not associated	PD

References

Pubmed ID	Year	Title	Citations
25720963	2015	Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.	297
19492085	2009	Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16150694	2005	Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.	75
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
25637383	2015	Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.	62
12218175	2002	Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.	60
19285944	2009	A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.	49
19458075	2009	Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.	47
19034380	2009	Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.	36

Citation

Dessen P

PPP3CA (protein phosphatase 3 catalytic subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41822/ppp3ca-(protein-phosphatase-3-catalytic-subunit-alpha)