PRC1 (protein regulator of cytokinesis 1)

2003-08-01  

Identity

HGNC
PRC1
LOCATION
15q26.1
LOCUSID
9055
ALIAS
ASE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9055
MIM: 603484
HGNC: 9341
Ensembl: ENSG00000198901

Variants:

dbSNP: 9055
ClinVar: 9055
TCGA: ENSG00000198901
COSMIC: PRC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198901ENST00000361188O43663
ENSG00000198901ENST00000394249O43663
ENSG00000198901ENST00000442656O43663
ENSG00000198901ENST00000555455G3V3N7
ENSG00000198901ENST00000556972H3BSJ8
ENSG00000198901ENST00000557905H0YM42
ENSG00000198901ENST00000559811H0YLA0
ENSG00000198901ENST00000559828H0YL53
ENSG00000198901ENST00000560423H0YNE4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate CITREACTOMER-HSA-5625900

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361359612023Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.0
372277232023CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.0
375635912023Protein regulator of cytokinesis 1: a potential oncogenic driver.0
375928952023Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.2
377382382023Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.0
361359612023Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.0
372277232023CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.0
375635912023Protein regulator of cytokinesis 1: a potential oncogenic driver.0
375928952023Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.2
377382382023Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.0
359830742022Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.1
365245122022PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.0
359830742022Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.1
365245122022PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.0
334803562021Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.24

Citation

Dessen P

PRC1 (protein regulator of cytokinesis 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41829