PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)

2003-11-01 Affiliation

Identity

HGNC

PRKAA2

LOCATION

1p32.2

LOCUSID

5563

ALIAS

AMPK,AMPK2,AMPKa2,PRKAA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5563
MIM: 600497
HGNC: 9377
Ensembl: ENSG00000162409

Variants:

dbSNP: 5563
ClinVar: 5563
TCGA: ENSG00000162409
COSMIC: PRKAA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162409	ENST00000371244	P54646
ENSG00000162409	ENST00000610361	A0A087WXX9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
Tight junction	KEGG	ko04530
Circadian rhythm	KEGG	ko04710
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
Tight junction	KEGG	hsa04530
Circadian rhythm	KEGG	hsa04710
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
FoxO signaling pathway	KEGG	hsa04068
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	REACTOME	R-HSA-2151209
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Import of palmitoyl-CoA into the mitochondrial matrix	REACTOME	R-HSA-200425
Integration of energy metabolism	REACTOME	R-HSA-163685
AMPK inhibits chREBP transcriptional activation activity	REACTOME	R-HSA-163680
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Insulin resistance	KEGG	hsa04931
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134983031	GPAM	Gene	Pathway	associated	22722338
PA142672073	CRTC2	Gene	Pathway	associated	22722338
PA189	HMGCR	Gene	Pathway	associated	22722338
PA24421	ACACA	Gene	Pathway	associated	22722338
PA24422	ACACB	Gene	Pathway	associated	22722338
PA30861	MLYCD	Gene	Pathway	associated	22722338
PA335	SREBF1	Gene	Pathway	associated	22722338
PA35879	SLC2A4	Gene	Pathway	associated	22722338
PA36198	STK11	Gene	Pathway	associated	22722338
PA37353	MLXIPL	Gene	Pathway	associated	22722338
PA37935	SIRT1	Gene	Pathway	associated	22722338
PA450395	metformin	Chemical	Pathway	associated	22722338
PA61	ATM	Gene	Pathway	associated	22722338
PA62	ATP1A1	Gene	Pathway	associated	23788015

References

Pubmed ID	Year	Title	Citations
38301894	2024	The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer.	0
38424484	2024	AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma.	1
38301894	2024	The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer.	0
38424484	2024	AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma.	1
36563529	2023	Changes in AMPK activity induces cellular senescence in human dental follicle cells.	1
36658117	2023	Impact of AMPK on cervical carcinoma progression and metastasis.	1
37014579	2023	AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation.	2
37874507	2023	Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients.	3
37962491	2023	Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.	1
36563529	2023	Changes in AMPK activity induces cellular senescence in human dental follicle cells.	1
36658117	2023	Impact of AMPK on cervical carcinoma progression and metastasis.	1
37014579	2023	AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation.	2
37874507	2023	Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients.	3
37962491	2023	Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.	1
34347929	2022	The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.	9

Citation

Dessen P

PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41845/img/favicon/teaching-explorer/