Identity
HGNC
LOCATION
1p32.2
LOCUSID
ALIAS
AMPK,AMPK2,AMPKa2,PRKAA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5563
MIM: 600497
HGNC: 9377
Ensembl: ENSG00000162409
Variants:
dbSNP: 5563
ClinVar: 5563
TCGA: ENSG00000162409
COSMIC: PRKAA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162409 | ENST00000371244 | P54646 |
| ENSG00000162409 | ENST00000610361 | A0A087WXX9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134983031 | GPAM | Gene | Pathway | associated | 22722338 | ||
| PA142672073 | CRTC2 | Gene | Pathway | associated | 22722338 | ||
| PA189 | HMGCR | Gene | Pathway | associated | 22722338 | ||
| PA24421 | ACACA | Gene | Pathway | associated | 22722338 | ||
| PA24422 | ACACB | Gene | Pathway | associated | 22722338 | ||
| PA30861 | MLYCD | Gene | Pathway | associated | 22722338 | ||
| PA335 | SREBF1 | Gene | Pathway | associated | 22722338 | ||
| PA35879 | SLC2A4 | Gene | Pathway | associated | 22722338 | ||
| PA36198 | STK11 | Gene | Pathway | associated | 22722338 | ||
| PA37353 | MLXIPL | Gene | Pathway | associated | 22722338 | ||
| PA37935 | SIRT1 | Gene | Pathway | associated | 22722338 | ||
| PA450395 | metformin | Chemical | Pathway | associated | 22722338 | ||
| PA61 | ATM | Gene | Pathway | associated | 22722338 | ||
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38301894 | 2024 | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | 0 |
| 38424484 | 2024 | AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma. | 1 |
| 38301894 | 2024 | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | 0 |
| 38424484 | 2024 | AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma. | 1 |
| 36563529 | 2023 | Changes in AMPK activity induces cellular senescence in human dental follicle cells. | 1 |
| 36658117 | 2023 | Impact of AMPK on cervical carcinoma progression and metastasis. | 1 |
| 37014579 | 2023 | AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation. | 2 |
| 37874507 | 2023 | Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients. | 3 |
| 37962491 | 2023 | Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers. | 1 |
| 36563529 | 2023 | Changes in AMPK activity induces cellular senescence in human dental follicle cells. | 1 |
| 36658117 | 2023 | Impact of AMPK on cervical carcinoma progression and metastasis. | 1 |
| 37014579 | 2023 | AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation. | 2 |
| 37874507 | 2023 | Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients. | 3 |
| 37962491 | 2023 | Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers. | 1 |
| 34347929 | 2022 | The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma. | 9 |
Citation
Dessen P
PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41845/prkaa2
