PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)

2003-11-01 Affiliation

Identity

HGNC

PRKAR1B

LOCATION

7p22.3

LOCUSID

5575

ALIAS

PRKAR1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5575
MIM: 176911
HGNC: 9390
Ensembl: ENSG00000188191

Variants:

dbSNP: 5575
ClinVar: 5575
TCGA: ENSG00000188191
COSMIC: PRKAR1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188191	ENST00000360274	P31321
ENSG00000188191	ENST00000400758	H7BYW5
ENSG00000188191	ENST00000403562	P31321
ENSG00000188191	ENST00000406797	P31321
ENSG00000188191	ENST00000414568	C9JR00
ENSG00000188191	ENST00000417852	C9IZL8
ENSG00000188191	ENST00000430040	C9JSK5
ENSG00000188191	ENST00000456696	C9J4C2
ENSG00000188191	ENST00000537384	P31321
ENSG00000188191	ENST00000544935	P31321

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Insulin signaling pathway	KEGG	ko04910
Insulin signaling pathway	KEGG	hsa04910
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
PKA-mediated phosphorylation of CREB	REACTOME	R-HSA-111931
PKA activation	REACTOME	R-HSA-163615
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
DARPP-32 events	REACTOME	R-HSA-180024
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'off' state	REACTOME	R-HSA-5610787
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Aquaporin-mediated transport	REACTOME	R-HSA-445717
Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME	R-HSA-432040
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME	R-HSA-381676
Glucagon signaling in metabolic regulation	REACTOME	R-HSA-163359
PKA activation in glucagon signalling	REACTOME	R-HSA-164378

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32895490	2021	Genomic and sequence variants of protein kinase A regulatory subunit type 1β (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.	7
33833410	2021	Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.	6
34716310	2021	EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression.	15
32895490	2021	Genomic and sequence variants of protein kinase A regulatory subunit type 1β (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.	7
33833410	2021	Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.	6
34716310	2021	EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression.	15
24722252	2014	PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.	27
25108559	2014	Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.	5
24722252	2014	PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.	27
25108559	2014	Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.	5
20379146	2010	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	25
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
20379146	2010	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	25
20588308	2010	Dengue hemorrhagic fever is associated with polymorphisms in JAK1.	12
12634056	2003	A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.	8

Citation

Dessen P

PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41850