ZMYND8 (zinc finger MYND-type containing 8)

2003-08-01  

Identity

HGNC
ZMYND8
LOCATION
20q13.12
LOCUSID
23613
ALIAS
PRKCBP1,PRO2893,RACK7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23613
MIM: 615713
HGNC: 9397
Ensembl: ENSG00000101040

Variants:

dbSNP: 23613
ClinVar: 23613
TCGA: ENSG00000101040
COSMIC: ZMYND8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101040ENST00000262975Q9ULU4
ENSG00000101040ENST00000311275Q9ULU4
ENSG00000101040ENST00000352431Q9ULU4
ENSG00000101040ENST00000355972Q9ULU4
ENSG00000101040ENST00000360911Q9ULU4
ENSG00000101040ENST00000372023Q9ULU4
ENSG00000101040ENST00000396281Q9ULU4
ENSG00000101040ENST00000435836Q5TH12
ENSG00000101040ENST00000441977Q5TH07
ENSG00000101040ENST00000446894Q5TH08
ENSG00000101040ENST00000446994Q9ULU4
ENSG00000101040ENST00000458360Q9ULU4
ENSG00000101040ENST00000461685Q9ULU4
ENSG00000101040ENST00000467200H7C4X9
ENSG00000101040ENST00000471951Q9ULU4
ENSG00000101040ENST00000536340Q9ULU4
ENSG00000101040ENST00000540497Q9ULU4
ENSG00000101040ENST00000611941A0A087WYS3
ENSG00000101040ENST00000617418A0A087WVZ6
ENSG00000101040ENST00000619049A0A087WV57

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359168662022De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.1
359168662022De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.1
331486602021ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.9
335939122021ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.11
343584472021ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.19
344627842021Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.2
331486602021ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.9
335939122021ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.11
343584472021ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.19
344627842021Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.2
319659802020A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.3
322245272020ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis.7
328326242020RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.16
333239282020Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.9
319659802020A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.3

Citation

Dessen P

ZMYND8 (zinc finger MYND-type containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41853/teaching-explorer/img/js/lib/jquery-3.5.1.min.js