Identity
HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
PKC-ZETA,PKC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5590
MIM: 176982
HGNC: 9412
Ensembl: ENSG00000067606
Variants:
dbSNP: 5590
ClinVar: 5590
TCGA: ENSG00000067606
COSMIC: PRKCZ
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128394595 | PLCH1 | Gene | Pathway | associated | |||
| PA134875646 | PLCZ1 | Gene | Pathway | associated | |||
| PA134914471 | PLCH2 | Gene | Pathway | associated | |||
| PA33384 | PLCB1 | Gene | Pathway | associated | |||
| PA33385 | PLCB2 | Gene | Pathway | associated | |||
| PA33386 | PLCB3 | Gene | Pathway | associated | |||
| PA33387 | PLCB4 | Gene | Pathway | associated | |||
| PA33388 | PLCD1 | Gene | Pathway | associated | |||
| PA33389 | PLCD3 | Gene | Pathway | associated | |||
| PA33390 | PLCD4 | Gene | Pathway | associated | |||
| PA33391 | PLCE1 | Gene | Pathway | associated | |||
| PA33392 | PLCG1 | Gene | Pathway | associated | 20124951 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20124951 | ||
| PA33394 | PLCL1 | Gene | Pathway | associated | |||
| PA33395 | PLCL2 | Gene | Pathway | associated | |||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 | ||
| PA39 | ADRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37029374 | 2023 | PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer. | 2 |
| 37340593 | 2023 | PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity. | 0 |
| 37890607 | 2023 | PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells. | 0 |
| 37029374 | 2023 | PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer. | 2 |
| 37340593 | 2023 | PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity. | 0 |
| 37890607 | 2023 | PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells. | 0 |
| 35017658 | 2022 | Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. | 1 |
| 35124330 | 2022 | Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c. | 3 |
| 35017658 | 2022 | Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. | 1 |
| 35124330 | 2022 | Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c. | 3 |
| 33444686 | 2021 | Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism. | 6 |
| 34063174 | 2021 | Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively. | 4 |
| 33444686 | 2021 | Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism. | 6 |
| 34063174 | 2021 | Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively. | 4 |
| 32330121 | 2020 | Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells. | 5 |
Citation
Dessen P
PRKCZ (protein kinase C zeta)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41863/prkcz
