PRKG1 (protein kinase cGMP-dependent 1)

2003-11-01  

Identity

HGNC
PRKG1
LOCATION
10q11.23
LOCUSID
5592
ALIAS
AAT8,PKG,PKG1,PRKG1B,PRKGR1B,cGK,cGK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5592
MIM: 176894
HGNC: 9414
Ensembl: ENSG00000185532

Variants:

dbSNP: 5592
ClinVar: 5592
TCGA: ENSG00000185532
COSMIC: PRKG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185532ENST00000373976B1ALS0
ENSG00000185532ENST00000373980Q13976
ENSG00000185532ENST00000401604Q13976
ENSG00000185532ENST00000643582A0A2R8YE50
ENSG00000185532ENST00000643704A0A2R8YH74
ENSG00000185532ENST00000645324A0A2R8Y507

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Long-term depressionKEGGko04730
Olfactory transductionKEGGko04740
Gap junctionKEGGhsa04540
Long-term depressionKEGGhsa04730
Olfactory transductionKEGGhsa04740
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Platelet activationKEGGhsa04611
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cGMP signalingKEGGhsa_M00694
cGMP signalingKEGGM00694
Regulation of lipolysis in adipocytesKEGGhsa04923
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386785522024Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation.0
386785522024Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation.0
366533762023Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway.6
366533762023Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway.6
366141102022Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene.1
366141102022Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene.1
327735982021Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.15
336283422021Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes.5
344001802021Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G.2
327735982021Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.15
336283422021Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes.5
344001802021Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G.2
319115802020O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth.97
320968712020Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer.9
325060522020A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.5

Citation

Dessen P

PRKG1 (protein kinase cGMP-dependent 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41864