PRPF19 (pre-mRNA processing factor 19)

2004-04-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
NMP200,PRP19,PSO4,SNEV,UBOX4,hPSO4
FUSION GENES

Other Information

Locus ID:

NCBI: 27339
MIM: 608330
HGNC: 17896
Ensembl: ENSG00000110107

Variants:

dbSNP: 27339
ClinVar: 27339
TCGA: ENSG00000110107
COSMIC: PRPF19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110107ENST00000227524Q9UMS4
ENSG00000110107ENST00000535326H0YGZ5
ENSG00000110107ENST00000540473H0YGF3
ENSG00000110107ENST00000541371F5GY56
ENSG00000110107ENST00000546152F5H2I0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384726682024PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells.0
384726682024PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells.0
367239742023PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism.5
379293502023PRPF19 promotes the proliferation, migration, and inhibits autophagy in prostate cancer by suppressing SLC40A1.0
380225152023Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer.1
367239742023PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism.5
379293502023PRPF19 promotes the proliferation, migration, and inhibits autophagy in prostate cancer by suppressing SLC40A1.0
380225152023Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer.1
335422122021A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.5
339543342021PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.8
341440372021PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA.19
348509362021A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes.1
335422122021A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.5
339543342021PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.8
341440372021PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA.19

Citation

Dessen P

PRPF19 (pre-mRNA processing factor 19)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41876/prpf19