PRSS21 (serine protease 21)

2003-06-01  

Identity

HGNC
PRSS21
LOCATION
16p13.3
LOCUSID
10942
ALIAS
ESP-1,ESP1,TEST1,TESTISIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10942
MIM: 608159
HGNC: 9485
Ensembl: ENSG00000007038

Variants:

dbSNP: 10942
ClinVar: 10942
TCGA: ENSG00000007038
COSMIC: PRSS21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007038ENST00000005995Q9Y6M0
ENSG00000007038ENST00000450020Q9Y6M0
ENSG00000007038ENST00000570594I3L2G7
ENSG00000007038ENST00000570629I3L3F7
ENSG00000007038ENST00000574265I3L3C7
ENSG00000007038ENST00000574813I3L0U2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
255199082015Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.21
255199082015Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.21
202116232010Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells.4
202116232010Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells.4
195712642009The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.38
195712642009The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.38
168105012006Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors.10
168105012006Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors.10
156852342005Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.16
156852342005Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.16

Citation

Dessen P

PRSS21 (serine protease 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41878