PSD (pleckstrin and Sec7 domain containing)

2003-02-01 Affiliation

Identity

HGNC

PSD

LOCATION

10q24.32

LOCUSID

5662

ALIAS

EFA6,EFA6A,PSD1,TYL

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5662
MIM: 602327
HGNC: 9507
Ensembl: ENSG00000059915

Variants:

dbSNP: 5662
ClinVar: 5662
TCGA: ENSG00000059915
COSMIC: PSD

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000059915	ENST00000020673	A5PKW4
ENSG00000059915	ENST00000406432	A5PKW4
ENSG00000059915	ENST00000461698	A0A1B0GUT6
ENSG00000059915	ENST00000611678	A5PKW4

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31844082	2019	The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles.	3
31844082	2019	The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles.	3
29246944	2018	EFA6 proteins regulate lumen formation through α-actinin 1.	11
29246944	2018	EFA6 proteins regulate lumen formation through α-actinin 1.	11
26330566	2016	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	12
26330566	2016	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	12
25355626	2015	The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance.	2
25355626	2015	The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance.	2
25114232	2014	EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.	20
25114232	2014	EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.	20
23603394	2013	EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.	4
23603394	2013	EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.	4
22002136	2012	Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis.	2
22179719	2012	Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis.	2
22002136	2012	Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis.	2

Citation

Dessen P

PSD (pleckstrin and Sec7 domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41882