Identity
HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
EFA6,EFA6A,PSD1,TYL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5662
MIM: 602327
HGNC: 9507
Ensembl: ENSG00000059915
Variants:
dbSNP: 5662
ClinVar: 5662
TCGA: ENSG00000059915
COSMIC: PSD
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000059915 | ENST00000020673 | A5PKW4 |
| ENSG00000059915 | ENST00000406432 | A5PKW4 |
| ENSG00000059915 | ENST00000461698 | A0A1B0GUT6 |
| ENSG00000059915 | ENST00000611678 | A5PKW4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Endocytosis | KEGG | ko04144 |
| Endocytosis | KEGG | hsa04144 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31844082 | 2019 | The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles. | 3 |
| 31844082 | 2019 | The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles. | 3 |
| 29246944 | 2018 | EFA6 proteins regulate lumen formation through α-actinin 1. | 11 |
| 29246944 | 2018 | EFA6 proteins regulate lumen formation through α-actinin 1. | 11 |
| 26330566 | 2016 | Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. | 12 |
| 26330566 | 2016 | Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. | 12 |
| 25355626 | 2015 | The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance. | 2 |
| 25355626 | 2015 | The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance. | 2 |
| 25114232 | 2014 | EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. | 20 |
| 25114232 | 2014 | EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. | 20 |
| 23603394 | 2013 | EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. | 4 |
| 23603394 | 2013 | EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. | 4 |
| 22002136 | 2012 | Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis. | 2 |
| 22179719 | 2012 | Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. | 2 |
| 22002136 | 2012 | Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis. | 2 |
Citation
Dessen P
PSD (pleckstrin and Sec7 domain containing)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41882/psd
