PTPN12 (protein tyrosine phosphatase non-receptor type 12)

2003-02-01  

Identity

HGNC
PTPN12
LOCATION
7q11.23
LOCUSID
5782
ALIAS
PTP-PEST,PTPG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5782
MIM: 600079
HGNC: 9645
Ensembl: ENSG00000127947

Variants:

dbSNP: 5782
ClinVar: 5782
TCGA: ENSG00000127947
COSMIC: PTPN12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127947ENST00000248594Q05209
ENSG00000127947ENST00000407343H3BM04
ENSG00000127947ENST00000415482Q05209
ENSG00000127947ENST00000418110C9J1X8
ENSG00000127947ENST00000433369C9JJC1
ENSG00000127947ENST00000435495Q05209
ENSG00000127947ENST00000440186C9JYA4
ENSG00000127947ENST00000447995F8WB51
ENSG00000127947ENST00000522115H0YC15
ENSG00000127947ENST00000523952H0YB59

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Signaling by PDGFREACTOMER-HSA-186797
Signaling by ERBB2REACTOMER-HSA-1227986
SHC1 events in ERBB2 signalingREACTOMER-HSA-1250196
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386128742024Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer.0
386128742024Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer.0
350633322023Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells.2
350633322023Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells.2
347840102022Protein tyrosine phosphatase non-receptor type 12 (PTPN12), negatively regulated by miR-106a-5p, suppresses the progression of hepatocellular carcinoma.3
350301042022PTP-PEST Regulated Membranous/Cytoplasmic Translocation of p120ctn in the Lung Cancer Resistance to Tyrosine Kinase Inhibitor.0
353640572022LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis.4
347840102022Protein tyrosine phosphatase non-receptor type 12 (PTPN12), negatively regulated by miR-106a-5p, suppresses the progression of hepatocellular carcinoma.3
350301042022PTP-PEST Regulated Membranous/Cytoplasmic Translocation of p120ctn in the Lung Cancer Resistance to Tyrosine Kinase Inhibitor.0
353640572022LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma progression via the mir-940/PTPN12 axis.4
333235052021The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation.9
333235052021The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation.9
325414672020Progress in the correlation between PTPN12 gene expression and human tumors.2
332920532020Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.0
325414672020Progress in the correlation between PTPN12 gene expression and human tumors.2

Citation

Dessen P

PTPN12 (protein tyrosine phosphatase non-receptor type 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41911/teaching-explorer/img/tumors-explorer/