PTPN18 (protein tyrosine phosphatase non-receptor type 18)

2003-06-01  

Identity

HGNC
PTPN18
LOCATION
2q21.1
LOCUSID
26469
ALIAS
BDP1,PTP-HSCF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26469
MIM: 606587
HGNC: 9649
Ensembl: ENSG00000072135

Variants:

dbSNP: 26469
ClinVar: 26469
TCGA: ENSG00000072135
COSMIC: PTPN18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072135ENST00000175756Q99952
ENSG00000072135ENST00000347849Q99952
ENSG00000072135ENST00000409022E7EMB8
ENSG00000072135ENST00000428843F8WBM9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368467162023PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.0
368467162023PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.0
320279482020Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.5
320279482020Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling.5
310340932019Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer.11
310340932019Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer.11
297424972018Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.14
297424972018Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.14
250810582014The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.45
250810582014The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.45
163037402005A bioinformatics analysis of protein tyrosine phosphatases in humans.3
163037402005A bioinformatics analysis of protein tyrosine phosphatases in humans.3
146606512004Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.23
146606512004Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.23

Citation

Dessen P

PTPN18 (protein tyrosine phosphatase non-receptor type 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41914