Identity
HGNC
LOCATION
2q21.1
LOCUSID
ALIAS
BDP1,PTP-HSCF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26469
MIM: 606587
HGNC: 9649
Ensembl: ENSG00000072135
Variants:
dbSNP: 26469
ClinVar: 26469
TCGA: ENSG00000072135
COSMIC: PTPN18
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000072135 | ENST00000175756 | Q99952 |
| ENSG00000072135 | ENST00000347849 | Q99952 |
| ENSG00000072135 | ENST00000409022 | E7EMB8 |
| ENSG00000072135 | ENST00000428843 | F8WBM9 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by ERBB2 | REACTOME | R-HSA-1227986 |
| Downregulation of ERBB2 signaling | REACTOME | R-HSA-8863795 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36846716 | 2023 | PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression. | 0 |
| 36846716 | 2023 | PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression. | 0 |
| 32027948 | 2020 | Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling. | 5 |
| 32027948 | 2020 | Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling. | 5 |
| 31034093 | 2019 | Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer. | 11 |
| 31034093 | 2019 | Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer. | 11 |
| 29742497 | 2018 | Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma. | 14 |
| 29742497 | 2018 | Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma. | 14 |
| 25081058 | 2014 | The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. | 45 |
| 25081058 | 2014 | The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. | 45 |
| 16303740 | 2005 | A bioinformatics analysis of protein tyrosine phosphatases in humans. | 3 |
| 16303740 | 2005 | A bioinformatics analysis of protein tyrosine phosphatases in humans. | 3 |
| 14660651 | 2004 | Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. | 23 |
| 14660651 | 2004 | Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. | 23 |
Citation
Dessen P
PTPN18 (protein tyrosine phosphatase non-receptor type 18)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41914/ptpn18
