Identity
HGNC
LOCATION
1q31.3
LOCUSID
ALIAS
B220,CD45,CD45R,GP180,L-CA,LCA,LY5,T200
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5788
MIM: 151460
HGNC: 9666
Ensembl: ENSG00000081237
Variants:
dbSNP: 5788
ClinVar: 5788
TCGA: ENSG00000081237
COSMIC: PTPRC
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation | associated | PD | 20309874, 23007924 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 20309874, 23007924 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 20309874, 23007924 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | 20309874, 23007924 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD | 20309874, 23007924 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38171036 | 2024 | Frequent expression of CD45RO memory T cell marker as well as low to high expression of PD-1 and PD-L1 inhibitory molecules in seminoma and dysgerminoma. | 0 |
| 38411434 | 2024 | [CD45 pre-exclusion from the tips of microvilli : role in their activation]. | 0 |
| 38575583 | 2024 | Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis. | 0 |
| 38880651 | 2024 | Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45 Protein Stability Regulator. | 0 |
| 38171036 | 2024 | Frequent expression of CD45RO memory T cell marker as well as low to high expression of PD-1 and PD-L1 inhibitory molecules in seminoma and dysgerminoma. | 0 |
| 38411434 | 2024 | [CD45 pre-exclusion from the tips of microvilli : role in their activation]. | 0 |
| 38575583 | 2024 | Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis. | 0 |
| 38880651 | 2024 | Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45 Protein Stability Regulator. | 0 |
| 36637125 | 2023 | Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection. | 0 |
| 36924233 | 2023 | CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells-Brief Report. | 1 |
| 37508538 | 2023 | CD45RA and CD45RO Are Regulated in a Cell-Type Specific Manner in Inflammation and Sepsis. | 0 |
| 37551093 | 2023 | Eosinophilic allergic rhinitis is strongly associated with the CD45RB(lo) subset of CD161(+) Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13. | 3 |
| 37676622 | 2023 | CD45(-) erythroid progenitor cells promote lymph node metastasis in gastric cancer by inducing a hybrid epithelial/mesenchymal state in lymphatic endothelial cells. | 0 |
| 37973964 | 2023 | Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease. | 0 |
| 37996489 | 2023 | PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma. | 0 |
Citation
Dessen P
PTPRC (protein tyrosine phosphatase receptor type C)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41925/ptprc
