Identity
HGNC
LOCATION
18p11.23
LOCUSID
ALIAS
PTPRL1,R-PTP-MU,RPTPM,RPTPU,hR-PTPu
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5797
MIM: 176888
HGNC: 9675
Ensembl: ENSG00000173482
Variants:
dbSNP: 5797
ClinVar: 5797
TCGA: ENSG00000173482
COSMIC: PTPRM
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell adhesion molecules (CAMs) | KEGG | ko04514 |
| Adherens junction | KEGG | ko04520 |
| Cell adhesion molecules (CAMs) | KEGG | hsa04514 |
| Adherens junction | KEGG | hsa04520 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 24583629 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | 24583629 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36436563 | 2023 | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. | 2 |
| 36927043 | 2023 | A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG. | 1 |
| 36436563 | 2023 | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. | 2 |
| 36927043 | 2023 | A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG. | 1 |
| 34225581 | 2021 | PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling. | 4 |
| 34225581 | 2021 | PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling. | 4 |
| 32663515 | 2020 | PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. | 13 |
| 32826853 | 2020 | High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer. | 16 |
| 32663515 | 2020 | PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. | 13 |
| 32826853 | 2020 | High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer. | 16 |
| 30274773 | 2018 | β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways. | 2 |
| 30274773 | 2018 | β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways. | 2 |
| 24771611 | 2014 | A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells. | 11 |
| 24771611 | 2014 | A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells. | 11 |
| 21743492 | 2012 | miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ. | 98 |
Citation
Dessen P
PTPRM (protein tyrosine phosphatase receptor type M)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41934/ptprm
