PTPRU (protein tyrosine phosphatase receptor type U)

2003-06-01  

Identity

HGNC
PTPRU
LOCATION
1p35.3
LOCUSID
10076
ALIAS
FMI,PCP-2,PTP,PTP-J,PTP-PI,PTP-RO,PTPPSI,PTPRO,PTPU2,R-PTP-PSI,R-PTP-U,hPTP-J
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10076
MIM: 602454
HGNC: 9683
Ensembl: ENSG00000060656

Variants:

dbSNP: 10076
ClinVar: 10076
TCGA: ENSG00000060656
COSMIC: PTPRU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060656ENST00000345512Q92729
ENSG00000060656ENST00000373779Q92729
ENSG00000060656ENST00000428026Q92729
ENSG00000060656ENST00000460170Q92729

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363324812022PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells.0
363324812022PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells.0
325915422020The receptor PTPRU is a redox sensitive pseudophosphatase.11
325915422020The receptor PTPRU is a redox sensitive pseudophosphatase.11
277610232016MicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU.38
277610232016MicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU.38
248761532014Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.18
253372162014Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.9
248761532014Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.18
253372162014Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.9
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
195283532009Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia.24
195283532009Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia.24
165645542006Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis.8

Citation

Dessen P

PTPRU (protein tyrosine phosphatase receptor type U)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41940/css/card-gene.css