PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

2003-11-01  

Identity

HGNC
PTPRZ1
LOCATION
7q31.32
LOCUSID
5803
ALIAS
HPTPZ,HPTPzeta,PTP-ZETA,PTP18,PTPRZ,PTPZ,R-PTP-zeta-2,RPTPB,RPTPbeta,phosphacan
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5803
MIM: 176891
HGNC: 9685
Ensembl: ENSG00000106278

Variants:

dbSNP: 5803
ClinVar: 5803
TCGA: ENSG00000106278
COSMIC: PTPRZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106278ENST00000393386P23471
ENSG00000106278ENST00000449182P23471
ENSG00000106278ENST00000650681A0A494C0U4
ENSG00000106278ENST00000650728A0A494C1R4
ENSG00000106278ENST00000650826A0A494C036
ENSG00000106278ENST00000651065A0A494C1H9
ENSG00000106278ENST00000651320A0A494C055
ENSG00000106278ENST00000651390A0A494C1B4
ENSG00000106278ENST00000651841A0A494C1J5
ENSG00000106278ENST00000651842A0A494C1B4
ENSG00000106278ENST00000651863A0A494C087
ENSG00000106278ENST00000652054A0A494C0V2
ENSG00000106278ENST00000652298P23471
ENSG00000106278ENST00000652708A0A494C1F0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375433612023Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.0
375433612023Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.0
354572332022Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.6
358835712022The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells.5
354572332022Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.6
358835712022The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells.5
336450092021High-sensitive clinical diagnostic method for PTPRZ1-MET and the characteristic protein structure contributing to ligand-independent MET activation.5
336450092021High-sensitive clinical diagnostic method for PTPRZ1-MET and the characteristic protein structure contributing to ligand-independent MET activation.5
313812042020A novel PTPRZ1-ETV1 fusion in gliomas.10
313812042020A novel PTPRZ1-ETV1 fusion in gliomas.10
313640032019MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion.6
313640032019MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion.6
296510062018Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.12
304974912018Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.22
296510062018Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.12

Citation

Dessen P

PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41941