RAB21 (RAB21, member RAS oncogene family)

2003-12-01 Affiliation

Identity

HGNC

RAB21

LOCATION

12q21.1

LOCUSID

23011

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23011
MIM: 612398
HGNC: 18263
Ensembl: ENSG00000080371

Variants:

dbSNP: 23011
ClinVar: 23011
TCGA: ENSG00000080371
COSMIC: RAB21

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000080371	ENST00000261263	Q9UL25
ENSG00000080371	ENST00000261263	A0A024RBA9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35993307	2023	RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1.	3
37369821	2023	The Regulatory Mechanism of Rab21 in Human Diseases.	0
35993307	2023	RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1.	3
37369821	2023	The Regulatory Mechanism of Rab21 in Human Diseases.	0
35163051	2022	Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway.	1
35220907	2022	Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis.	3
35163051	2022	Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway.	1
35220907	2022	Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis.	3
30471852	2019	Requirement of Rab21 in LPS-induced TLR4 signaling and pro-inflammatory responses in macrophages and monocytes.	8
31383875	2019	Colorectal cancer cells respond differentially to autophagy inhibition in vivo.	30
30471852	2019	Requirement of Rab21 in LPS-induced TLR4 signaling and pro-inflammatory responses in macrophages and monocytes.	8
31383875	2019	Colorectal cancer cells respond differentially to autophagy inhibition in vivo.	30
28547526	2018	Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.	7
28547526	2018	Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.	7
29270202	2017	Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.	16

Citation

Dessen P

RAB21 (RAB21, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41966/gene-explorer/img/meetings/