RAB27B (RAB27B, member RAS oncogene family)

2003-11-01  

Identity

HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
C25KG
FUSION GENES

Other Information

Locus ID:

NCBI: 5874
MIM: 603869
HGNC: 9767
Ensembl: ENSG00000041353

Variants:

dbSNP: 5874
ClinVar: 5874
TCGA: ENSG00000041353
COSMIC: RAB27B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000041353ENST00000262094O00194
ENSG00000041353ENST00000586570K7ES41
ENSG00000041353ENST00000592334K7EJ38

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380366302024RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.4
380366302024RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.4
365813402023Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.4
370779382023RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.1
373179632023RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.3
376413722023Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.0
365813402023Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.4
370779382023RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.1
373179632023RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.3
376413722023Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.0
359856822022RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.4
359856822022RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.4
332852902021Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.0
346863302021NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.10
332852902021Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.0

Citation

Dessen P

RAB27B (RAB27B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41973/rab27b