RAB35 (RAB35, member RAS oncogene family)

2003-12-01  

Identity

HGNC
RAB35
LOCATION
12q24.23
LOCUSID
11021
ALIAS
H-ray,RAB1C,RAY
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11021
MIM: 604199
HGNC: 9774
Ensembl: ENSG00000111737

Variants:

dbSNP: 11021
ClinVar: 11021
TCGA: ENSG00000111737
COSMIC: RAB35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111737ENST00000229340Q15286
ENSG00000111737ENST00000534951Q15286
ENSG00000111737ENST00000538903F5H157
ENSG00000111737ENST00000544304F5H7F8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384326372024A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35.0
384326372024A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35.0
367258862023Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.6
374542962023DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.2
378751182023MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis.1
367258862023Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.6
374542962023DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.2
378751182023MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis.1
344482132022Rab35 regulates insulin secretion via phogrin in pancreatic β cells.0
350007522022BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.9
352647102022Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.13
344482132022Rab35 regulates insulin secretion via phogrin in pancreatic β cells.0
350007522022BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.9
352647102022Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.13
334435702021An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.12

Citation

Dessen P

RAB35 (RAB35, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41983/js/favicon/gene-fusions-explorer/gene-fusions/?id=41983