RAB5B (RAB5B, member RAS oncogene family)

2003-02-01 Affiliation

Identity

HGNC

RAB5B

LOCATION

12q13.2

LOCUSID

5869

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5869
MIM: 179514
HGNC: 9784
Ensembl: ENSG00000111540

Variants:

dbSNP: 5869
ClinVar: 5869
TCGA: ENSG00000111540
COSMIC: RAB5B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111540	ENST00000360299	P61020
ENSG00000111540	ENST00000360299	A0A024RB09
ENSG00000111540	ENST00000548068	F8VUA5
ENSG00000111540	ENST00000549505	F8VPW9
ENSG00000111540	ENST00000549915	F8VWZ7
ENSG00000111540	ENST00000551459	F8VVZ0
ENSG00000111540	ENST00000553116	P61020
ENSG00000111540	ENST00000553116	A0A024RB09
ENSG00000111540	ENST00000628569	F8VPW9

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Ras signaling pathway	KEGG	hsa04014
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Neutrophil degranulation	REACTOME	R-HSA-6798695
RAB GEFs exchange GTP for GDP on RABs	REACTOME	R-HSA-8876198
TBC/RABGAPs	REACTOME	R-HSA-8854214
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36423778	2023	Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome.	2
37882757	2023	hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.	0
36423778	2023	Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome.	2
37882757	2023	hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.	0
35121658	2022	A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C.	5
35121658	2022	A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C.	5
31036605	2019	Association of single nucleotide polymorphisms in the RAB5B gene 3'UTR region with polycystic ovary syndrome in Chinese Han women.	5
31118260	2019	Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.	13
31036605	2019	Association of single nucleotide polymorphisms in the RAB5B gene 3'UTR region with polycystic ovary syndrome in Chinese Han women.	5
31118260	2019	Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.	13
29746865	2018	MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells.	58
29746865	2018	MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells.	58
25605758	2015	An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.	47
25605758	2015	An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.	47
24106282	2013	Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome.	51

Citation

Dessen P

RAB5B (RAB5B, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42002