RAD21 (RAD21 cohesin complex component)

2003-05-01  

Identity

HGNC
RAD21
LOCATION
8q24.11
LOCUSID
5885
ALIAS
CDLS4,HR21,HRAD21,MCD1,MGS,NXP1,SCC1,hHR21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5885
MIM: 606462
HGNC: 9811
Ensembl: ENSG00000164754

Variants:

dbSNP: 5885
ClinVar: 5885
TCGA: ENSG00000164754
COSMIC: RAD21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164754ENST00000297338O60216
ENSG00000164754ENST00000297338A0A024R9J0
ENSG00000164754ENST00000517485E5RFV8
ENSG00000164754ENST00000517749E5RG18
ENSG00000164754ENST00000518055E5RFZ5
ENSG00000164754ENST00000519837E5RJK5
ENSG00000164754ENST00000520992E5RIN7
ENSG00000164754ENST00000522699E5RJW1
ENSG00000164754ENST00000523986E5RI01

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383789672024NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer.0
383789672024NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer.0
370948502023Interference with XPO1 Suppresses the Stemness and Radioresistance of CD44 Positive Cervical Cancer Cells via Binding with Rad21.0
373810362023RAD21 is the core subunit of the cohesin complex involved in directing genome organization.9
380663192023CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.0
381370342023Cornelia de Lange Syndrome Caused by an Intragenic Heterozygous Deletion in RAD21 Detected through Very-High-Resolution Chromosomal Microarray Analysis.0
370948502023Interference with XPO1 Suppresses the Stemness and Radioresistance of CD44 Positive Cervical Cancer Cells via Binding with Rad21.0
373810362023RAD21 is the core subunit of the cohesin complex involved in directing genome organization.9
380663192023CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.0
381370342023Cornelia de Lange Syndrome Caused by an Intragenic Heterozygous Deletion in RAD21 Detected through Very-High-Resolution Chromosomal Microarray Analysis.0
352272902022A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres.3
355635652022Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma.2
356540042022Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients.1
359063552022Genetic variation as a long-distance modulator of RAD21 expression in humans.1
352272902022A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres.3

Citation

Dessen P

RAD21 (RAD21 cohesin complex component)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42026/js/favicon/cancer-prone-explorer/img/logo-atlas-4.svg