RALA (RAS like proto-oncogene A)

2003-02-01  

Identity

HGNC
LOCATION
7p14.1
LOCUSID
ALIAS
HINCONS,RAL
FUSION GENES

Other Information

Locus ID:

NCBI: 5898
MIM: 179550
HGNC: 9839
Ensembl: ENSG00000006451

Variants:

dbSNP: 5898
ClinVar: 5898
TCGA: ENSG00000006451
COSMIC: RALA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006451ENST00000005257P11233
ENSG00000006451ENST00000434466H7C3P7
ENSG00000006451ENST00000436179C9JPE8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382868212024Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.2
382868212024Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.2
368178612023Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma.0
371167042023Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production.1
368178612023Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma.0
371167042023Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production.1
347676742022Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.5
347676742022Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.5
340097152021Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.7
340965032021RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.8
341189602021The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.4
343203412021RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.7
349444582021RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth.0
340097152021Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.7
340965032021RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.8

Citation

Dessen P

RALA (RAS like proto-oncogene A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42035/css/tumors-explorer/js/template.js